If your Vista getting blank black screen and nothing happens after logging it in. And if it can only run from Safe Mode and shows "Application cannot be excuted. The file is infected. Please activate your antivirus software" if you run System Restore feature. It probably the computer has virus or malware in it. To solve, under Safe Mode, run Internet Explorer, go to 'Tools', then switch the tab to 'Internet Options', then 'Connections', and choose 'LAN Settings'. Remove the mark from use Proxy Server.
For further, get a good anti-virus and anti-malware, then scan your computer to remove any threat from the computer.